Gn and Gc are integral transmembrane proteins, which play an important role in viral attachment, membrane fusion and the induction of the host’s immune response.
The large (L) genomic segment encodes for the RNA-dependent RNA polymerase, while the medium (M) segment encodes for the surface glycoproteins Gn and Gc and the non-structural protein NSm. The tripartite single-stranded RNA genome encodes for only four structural and two non-structural proteins. In general, viruses of the genus Orthobunyavirus are spherical, about 100 nm in diameter and relatively simple in their composition. Schmallenberg virus (SBV), Akabane virus (AKAV) and Shuni virus (SHUV). Of these, the Simbu serogroup is not only one of the largest, but also the most important group in terms of veterinary public health, since it contains e.g. One of the genera that belongs to the family Peribunyaviridae is the Orthobunyavirus genus, which contains more than 170 insect-transmitted viruses assigned to 18 serogroups. The order Bunyavirales consists of 46 genera assigned to 12 families and accommodates thousands of viruses with linear, segmented, single-stranded RNA genome.
In contrast to coronaviruses, which are widely known nowadays, bunyaviruses are less well-known, although they represent one of the largest group of viruses.
0 kommentar(er)
